Association between pelvic inflammatory disease and subsequent salpingectomy on the risk for ovarian cancer

AimSalpingectomy is associated with a lower risk for ovarian cancer, suggesting that the fallopian tubes constitute origin of disease. It unclear whether observed effect mediated by pelvic inflammatory disease (PID); major indication salpingectomy and implicated in aetiology cancer.MethodsIn this population-based cohort study, we used nationwide registry-based data on women exposed PID without subsequent (n = 97,912) compared unexposed population 5,429,174) between 1973 2010. The hormone treatment was considered subanalysis.ResultsOf women, 9538 underwent during study period. There significant association cancer (hazard ratio [HR] 1.44, 95% confidence interval [CI] 1.31–1.59), whereas an inverse (HR 0.55, CI 0.36–0.83). Salpingectomy performed other indications 24,895) incidence 0.72, 0.56–0.93). No modification use oral contraceptives or hormonal replacement therapy.ConclusionSalpingectomy regardless indication.